Description
The Cardiolipin Antibody IgG Test detects the presence of specific autoantibodies (IgG isotype) that attack cardiolipins—substances found in the outer membranes of blood platelets and cells. When these antibodies are present, they can interfere with the body’s clotting regulation. This test is a primary marker for diagnosing Antiphospholipid Syndrome (APS), an autoimmune disorder that increases the risk of blood clots.
Why is this test recommended?
Doctors typically order this test to investigate the underlying causes of:
Unexplained Blood Clots: Deep Vein Thrombosis (DVT), Pulmonary Embolism (PE), or arterial thrombosis.
Recurrent Miscarriages: Frequent pregnancy loss or complications like pre-eclampsia.
Stroke: Particularly in younger individuals without typical risk factors.
Autoimmune Screening: Evaluation for Systemic Lupus Erythematosus (SLE) or other connective tissue disorders.
Understanding the IgG Isotype
While cardiolipin antibodies come in three classes (IgG, IgM, IgA), the IgG class is the most strongly associated with the clinical complications of Antiphospholipid Syndrome, specifically thrombosis (clotting) and fetal loss.
Patient Preparation
Fasting: No fasting is usually required for this test.
Diet & Meds: You may eat and drink normally. However, please inform the lab if you are taking blood thinners (anticoagulants) or have a current infection (like Syphilis), as these can sometimes influence results.
How is the sample collected?
A standard blood draw is performed by a phlebotomist.
A vein is located in the arm.
A small amount of blood (approx. 3-5ml) is drawn into a serum tube.
The procedure takes less than 5 minutes and involves minimal discomfort.
