Description
This diagnostic test, Anti Thrombin Iii, is offered by Kashmir Online Lab in the HAEMATOLOGY department. It helps in assessing relevant health parameters. For detailed information or booking, visit our website or contact us.
Overview: Antithrombin III (AT III) is a protein produced by the liver that acts as a natural “blood thinner.” It regulates the blood clotting process by inhibiting Thrombin and other clotting factors. If a patient does not have enough functional Antithrombin III, their blood may clot too easily.
Clinical Significance: This test is a critical component of a “Thrombophilia Screening” (investigation of clotting disorders).
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Deficiency (Low Levels): Patients with low AT III are at significant risk for developing abnormal blood clots in the veins (venous thromboembolism). Deficiency can be inherited (genetic) or acquired due to liver disease, nephrotic syndrome, or extensive blood clots.
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Heparin Resistance: Antithrombin III is required for the blood thinner Heparin to work. If a patient is on Heparin but their blood is not thinning as expected, this test checks if an AT III deficiency is the cause.
When is this test recommended?
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To investigate the cause of recurrent or unprovoked blood clots (thrombosis).
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To screen family members of patients with known hereditary Antithrombin deficiency.
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To evaluate patients who are resistant to Heparin therapy.
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Note: It is usually not tested during an acute clotting event or immediately after starting anticoagulants, as these can temporarily lower AT III levels and give misleading results.
Sample Requirements:
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Specimen: Plasma.
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Container: Light Blue Top Tube (Sodium Citrate).
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Crucial Handling: The tube must be filled completely to the fill line to ensure the correct ratio of blood to anticoagulant (9:1). Inaccurate filling will result in rejection of the sample.
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Preparation: No fasting is typically required, though patients should inform the lab if they are currently taking blood thinners.
