Description
Overview: Cancer Antigen 72-4 (CA 72-4) is a mucin-like glycoprotein found on the surface of many cancer cells. While it is the premier marker for stomach (gastric) cancer, it is also a valuable marker for mucinous ovarian cancer. Its greatest strength lies in its specificity—unlike CEA or CA 19-9, CA 72-4 is rarely elevated in benign (non-cancerous) inflammation, making it a reliable tool for distinguishing between benign conditions and malignant tumors.
Clinical Significance:
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Gastric Cancer: It is currently the most sensitive marker for monitoring stomach cancer treatment. A drop in levels typically indicates successful surgery or chemotherapy, while rising levels are a strong indicator of tumor recurrence or metastasis.
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Ovarian Cancer: It acts as a complementary marker to CA-125, specifically for detecting mucinous types of ovarian cancer that CA-125 often misses.
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Benign vs. Malignant: High levels are very strongly correlated with cancer, as benign gastrointestinal diseases (like ulcers or gastritis) rarely cause significant elevations.
When is this test recommended?
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To establish a baseline in patients newly diagnosed with gastric carcinoma.
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To monitor patients undergoing chemotherapy for stomach or ovarian cancer.
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To check for cancer return (recurrence) during follow-up visits after surgery.
Sample Requirements:
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Specimen: Serum (Blood).
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Container: Gold Top (SST) or Red Top Tube.
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Preparation: No special preparation or fasting is required.
