Description
Overview: Cancer Antigen 72-4 (CA 72-4) is a protein found on the surface of certain cancer cells. While it is most strongly associated with stomach (gastric) cancer, it can also be elevated in ovarian cancers (specifically the mucinous type) and colorectal cancers. Unlike some other markers, CA 72-4 is highly specific, meaning it is rarely elevated in benign (non-cancerous) conditions, making it a reliable tool for confirming a cancer diagnosis when used with other tests.
Clinical Significance:
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Gastric Cancer Monitoring: This is the most sensitive marker for monitoring the progression of stomach cancer. If levels drop after surgery, the treatment was likely successful. If levels rise later, it may indicate the cancer has returned (recurrence).
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Ovarian Cancer: It serves as a complementary marker to CA-125, particularly for detecting mucinous ovarian tumors which CA-125 might miss.
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Differentiation: Because it is rarely elevated in benign gastrointestinal diseases (like ulcers), it helps distinguish between benign conditions and malignant tumors.
When is this test recommended?
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For patients diagnosed with gastric carcinoma to establish a baseline before treatment.
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During chemotherapy to track if the tumor is shrinking.
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Regularly after treatment to catch any relapse early.
Sample Requirements:
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Specimen: Serum (Blood).
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Container: Gold Top (SST) or Red Top Tube.
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Preparation: No special preparation (fasting) is typically required, though standard blood draw protocols apply.
