Description
Overview: Brucellosis (also known as Malta fever or undulant fever) is an infectious disease caused by Brucella bacteria. The Brucella Antibody (Total) By Agglutination test, often referred to as the Standard Agglutination Test (SAT) or Wright’s test, measures the total level of antibodies (both IgM and IgG) in the blood serum that react to Brucella antigens. “Agglutination” refers to the laboratory method where these antibodies cause bacterial particles to clump together, indicating a positive result.
Clinical Significance: This test is a primary screening tool for diagnosing brucellosis.
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Positive Result: Indicates exposure to Brucella bacteria. A high or rising antibody level (titer) across two samples taken weeks apart typically suggests an active or recent infection.
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Negative Result: Suggests no prior exposure or that it is too early in the infection for antibodies to be detected.
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Interpretation: Results must be interpreted in the context of the patient’s symptoms and history, as low-level positive results can sometimes persist for years after a past infection.
When is this test recommended?
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To investigate symptoms like prolonged or recurring fever, sweating, joint and muscle pain, fatigue, and headache.
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For individuals with a history of consuming unpasteurized milk or cheese.
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For people in high-risk occupations, such as veterinarians, farmers, slaughterhouse workers, or laboratory personnel who work with animals or bacteria.
Sample Requirements:
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Specimen: Serum.
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Container: Gold Top (SST) or Red Top Tube.
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Preparation: No fasting is typically required.
